Pre-Conference Satellite Meetings

Osteoporosis: diagnosis, management and therapy

Date: Saturday 17 June 2017

Time: 10:30am - 2:00pm

Location: A2

Precis: On the 17th of June there will be a pre-meeting satellite symposium dedicated to the Diagnosis, Management and Therapy of Osteoporosis. This session is designed for clinicians who treat patients with osteoporosis and trainees. This will be an informal interactive session bringing together eminent clinicians from Australia/New Zealand and overseas outlining practical approaches to osteoporosis care. The session will take a practical approach to the diagnosis of osteoporosis and assessment of fracture risk, approaches to treatment, and aspects of service organisation and osteoporosis prevention.

This session is complimentary, however you must sign up for it via your conference registration here.


 

The Genetics of Bone Disease: practical approaches and applications

Date: Saturday 17 June 2017

Time: 9:30am - 11:30am

Location: A1

Precis: This symposium will appeal to anyone seeking a better understanding of how biological and statistical approaches can be used to study the genetics of osteoporosis and related bone diseases. Each talk consists of a short theoretical component that introduces a statistical-genetic or molecular method and thereafter discusses its application to genetic investigations of bone disease. The symposium has been divided into two parts. In part one, we will describe the genetic underpinnings of mono- and polygenetic bone disease, and discuss how genome-wide association methods together with functional studies of model organisms can identify genetic elements involved in bone homeostasis. In part two, we discuss how the results of genetic association studies can be leveraged to identify novel therapeutic and lifestyle interventions.

Symposium Chairs:
Aideen Mclnerney-Leo (Queensland University of Technology) and John Kemp (University of Queensland)

Part 1: Investigating the Genetic Architecture of osteoporosis and related bone diseases.

09:30 - 09:45: The genetic architecture of bone disease and implications for adverse outcomes.

Speaker: Prof Emma Duncan (Queensland University of Technology)

09:50 - 10:05: Genetic investigations of monogenic bone disease using exome sequencing.

Speaker: Dr Aideen Mclnerney-Leo (Queensland University of Technology)

10:10 - 10:25: Genetic investigations of osteoporosis using genome-wide association studies.

Speaker: A/Prof Paul Leo (Queensland University of Technology)             

10:30 - 10:45: Fine mapping and characterisation of osteoporosis associated genes through skeletal phenotyping of animal models.

Speaker: Mr Scott Youlten (Garvan Institute of Medical Research)

Part 2: Application of Genetic Studies for Osteoporosis Intervention 

10:50 - 11:05: Informing drug discovery and drug repositioning through genetic association studies.

Speaker: Prof Matt Brown (Queensland University of Technology)

11:10 - 11:25: Leveraging Mendelian randomization strategies to identify modifiable lifestyle factors causally related to osteoporosis pathogenesis.

Speaker: Prof David Evans (University of Queensland)

This session is complimentary, however you must sign up for it via your conference registration here.


 

Bone quality: what is it and how do we measure it?

Date: Saturday 17 June 2017

Time: 12:00pm - 2:00pm

Location: A1

The objective of this workshop is to discuss the current understanding of bone quality and different approaches that can be employed to measure it. Bone is a hierarchical, complex composite structure and depending on the scale and methods used to interrogate it, it will give corresponding answers. The talks in this workshop will range from a clinical to a laboratory perspective, including imaging, material and mechanical characterisation, each with their advantages and limitations. It is intended to be an interactive workshop, aimed at generating discussions and exchanging points of view among clinicians, bone biologists, engineers and physicists.

Chairs:
Egon Perilli (Flinders University, Adelaide), Christina Vrahnas (St. Vincent Institute/The University of Melbourne)


1. What determines bone quality and why is it important?
Ego Seeman (Austin Health/The University of Melbourne)

2. Bone histology: benefits, limitations and pitfalls
Natalie Sims (St. Vincent Institute/The University of Melbourne)

3. FTIR imaging in bone: what does it tell us?
Christina Vrahnas (St. Vincent Institute/The University of Melbourne) 

4. Other imaging approaches: Ultrasound
Christian Langton (Queensland University of Technology, Brisbane)

5. Mechanical testing combined with imaging
Egon Perilli (Flinders University, Adelaide) 

This session is complimentary, however you must sign up for it via your conference registration here.


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